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Ischemic Organ Injury Lab »  People »  Principal Investigators »  Claus Niemann, M.D.
Claus U. Niemann, M.D.

Claus U. Niemann, M.D.

Professor of Anesthesia and Surgery

Department of Anesthesia & Perioperative Care
Department of Surgery

Co-Director, Ischemic Organ Injury Lab

Contact Information

University of California, San Francisco
500 Parnassus MUE 4th Floor
Box 0648
San Francisco, Ca 94143-0648
Tel: 415-502-2162
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  • 1986-93, Ludwig-Maximilians University, Munich, Germany, M.D.
  • 1993-94  Intern ;  City Hospital St. Georg,, University of Hamburg, Germany and Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
  • 1996-99, University of California, San Francisco, Resident, Anesthesia
  • 1999-01, University of California, San Francisco, Fellow, Liver Transplant Research
  • 1994-96, Department of Anesthesiology, Northwestern University, Chicago, Illinois, Fellow, Postdoctoral Research
  • American Board of Anesthesiology
  • Department of Anesthesia and Perioperative Care
  • Department of Surgery, Division of Transplantation
  • UCSF Liver Center
  • Kidney Transplantation
  • Liver Transplantation
  • Pancreas Transplantation
  • View Research Profile at UCSF Clinical & Translational Science Institute

  • Inflammatory response to injuryIschemia reperfusion injury
  • Intensive Insulin Therapy in Deceased Donors-to improve renal allograft function and transplanted allograft outcomes
  • Liver transplantation
  • Metabolomics
  • Organ donation
  • Renal and hepatic injury during surgery

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. 

Most recent publications from a total of 88
  1. Malinoski D, Patel MS, Axelrod DA, Broglio K, Lewis RJ, Groat T, Niemann CU. Therapeutic Hypothermia in Organ Donors: Follow-up and Safety Analysis. Transplantation. 2019 Nov; 103(11):e365-e368. View in PubMed
  2. Axelrod DA, Malinoski D, Patel MS, Broglio K, Lewis R, Groat T, Lentine KL, Schnitzler M, Niemann CU. Modeling the economic benefit of targeted mild hypothermia in deceased donor kidney transplantation. Clin Transplant. 2019 Jul; 33(7):e13626. View in PubMed
  3. Sally MB, Ellis MK, Hutchens M, Groat T, Swanson E, Patel MS, Niemann CU, Malinoski DJ. Deceased organ donor factors influencing pancreatic graft transplantation and survival. Clin Transplant. 2019 Jun; 33(6):e13571. View in PubMed
  4. Niemann CU, Matthay MA, Ware LB. The Continued Need for Clinical Trials in Deceased Organ Donor Management. Transplantation. 2019 Jul; 103(7):1298-1299. View in PubMed
  5. Adelmann D, Roll GR, Kothari R, Syed S, Burdine LJ, Tavakol M, Niemann CU. The Impact of Deceased Donor Liver Extraction Time on Early Allograft Function in Adult Liver Transplant Recipients. Transplantation. 2018 Nov; 102(11):e466-e471. View in PubMed
  6. Adelmann D, Olmos A, Liu LL, Feiner JR, Roll GR, Burdine L, Tavakol M, Syed S, Orandi BJ, Niemann CU. Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy. Transplantation. 2018 05; 102(5):e229-e235. View in PubMed
  7. Adelmann D, Bicknell L, Niemann CU, Feiner J, Roll GR, Burdine L, Whitlock EL. Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis. Clin Transplant. 2018 05; 32(5):e13238. View in PubMed
  8. Souter MJ, Eidbo E, Findlay JY, Lebovitz DJ, Moguilevitch M, Neidlinger NA, Wagener G, Paramesh AS, Niemann CU, Roberts PR, Pretto EA. Organ Donor Management: Part 1. Toward a Consensus to Guide Anesthesia Services During Donation After Brain Death. Semin Cardiothorac Vasc Anesth. 2018 Jun; 22(2):211-222. View in PubMed
  9. Niemann CU, Broglio K, Malinoski D. Comments on "Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation". Am J Transplant. 2018 03; 18(3):763. View in PubMed
  10. Linecker M, Krones T, Berg T, Niemann CU, Steadman RH, Dutkowski P, Clavien PA, Busuttil RW, Truog RD, Petrowsky H. Potentially inappropriate liver transplantation in the era of the "sickest first" policy - A search for the upper limits. J Hepatol. 2018 04; 68(4):798-813. View in PubMed
  11. View All Publications
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