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Ischemic Organ Injury Lab »  People »  Principal Investigators »  Claus Niemann, M.D.
Claus U. Niemann, M.D.

Claus U. Niemann, M.D.

Professor of Anesthesia and Surgery

Department of Anesthesia & Perioperative Care
Department of Surgery

Co-Director, Ischemic Organ Injury Lab

Contact Information

University of California, San Francisco
500 Parnassus MUE 4th Floor
Box 0648
San Francisco, Ca 94143-0648
Tel: 415-502-2162
Claus.Niemann@ucsf.edu
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  • 1986-93, Ludwig-Maximilians University, Munich, Germany, M.D.
  • 1993-94  Intern ;  City Hospital St. Georg,, University of Hamburg, Germany and Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
  • 1996-99, University of California, San Francisco, Resident, Anesthesia
  • 1999-01, University of California, San Francisco, Fellow, Liver Transplant Research
  • 1994-96, Department of Anesthesiology, Northwestern University, Chicago, Illinois, Fellow, Postdoctoral Research
  • American Board of Anesthesiology
  • Department of Anesthesia and Perioperative Care
  • Department of Surgery, Division of Transplantation
  • UCSF Liver Center
  • Kidney Transplantation
  • Liver Transplantation
  • Pancreas Transplantation
  • View Research Profile at UCSF Clinical & Translational Science Institute

  • Inflammatory response to injuryIschemia reperfusion injury
  • Intensive Insulin Therapy in Deceased Donors-to improve renal allograft function and transplanted allograft outcomes
  • Liver transplantation
  • Metabolomics
  • Organ donation
  • Renal and hepatic injury during surgery
My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury.

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. 

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MOST RECENT PUBLICATIONS FROM A TOTAL OF 101
Data provided by UCSF Profiles, powered by CTSI
  1. Terrault NA, Burton J, Ghobrial M, Verna E, Bayer J, Klein C, Victor D, Mohan S, Trotter J, Dodge J, Niemann CU, Rubin RA. Prospective Multicenter Study of Early Antiviral Therapy in Liver and Kidney Transplant Recipients of HCV-Viremic Donors. Hepatology. 2020 Sep 14. View in PubMed
  2. Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Nat Commun. 2020 08 27; 11(1):4289. View in PubMed
  3. Syed SM, Gardner J, Roll G, Webber A, Mehta N, Shoji J, Adelmann D, Niemann C, Braun HJ, Mello A, Yao F, Posselt A, Kang SM, Hirose R, Roberts J, Feng S, Ascher N, Stock P, Freise C. COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions. Transplantation. 2020 Jun 29. View in PubMed
  4. Swanson EA, Adams T, Patel MS, De La Cruz S, Hutchens M, Khush K, Sally MB, Niemann CU, Groat T, Malinoski DJ. Impact of Deceased Donor Management on Donor Heart Use and Recipient Graft Survival. J Am Coll Surg. 2020 Sep; 231(3):351-360.e5. View in PubMed
  5. Swanson EA, Patel MS, Groat T, Jameson NE, Ellis MKM, Hutchens MP, Niemann CU, Malinoski DJ, Sally MB. Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function. J Trauma Acute Care Surg. 2020 06; 88(6):783-788. View in PubMed
  6. View All Publications

 

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