Translating Discoveries from Bench to Bedside

Our laboratory, led by an anesthesiologist and a transplant surgeon, is uniquely positioned to investigate these clinically relevant issues and to translate these findings into trials that may change the way we practice medicine and surgery in an extremely rapid fashion. We literally go back and forth between findings in the clinic, and findings in the laboratory which direct our research in both arenas. We perform research both in the experimental laboratory as well as on outcomes related to patients.

As two examples of this kind of research, we have found that mild hypothermia is extremely beneficial at ameliorating ischemia-reperfusion injury of the liver, even in fatty livers which are exceedingly susceptible to ischemic injury. We have also found that high blood sugar is can greatly exacerbate ischemic injury of the kidney. Both of these findings may have an immediate impact on how we deal with ischemia of the liver or of the kidney in a variety of settings, including vascular, urologic, oncologic and transplant surgery.